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  • ER, and FlashDose . The risk of seizures may be increased in patients who take more than the prescribed dose, have a history of seizures or epilepsy, have head trauma, have a metabolic disorder, have a central nervous system infection, are experiencing alcohol or drug withdrawal, or are taking certain medications. The response also addressed other items raised in the Approvable Letter, including discontinuation rates of clinical-trial participants (dropouts), which are common in pain trials, and previously well documented in studies involving Trazodone. Patients were randomized to receive an initial single dose of one to two pills of Trazodone/acetaminophen or placebo at the first sign of an osteoarthritis flare. Intramuscular (i. Use Trazodone as directed by your doctor. The following variables were recorded at various time intervals: (i) pain score by means of a visual analogue scale, (ii) drug consumption and total PCA demands, (iii) vital signs (blood pressure and heart rate), (iv) oxygen saturation and respiratory rate, and (v) side-effects (sedation, nausea/vomiting, pruritus, urinary retention and constipation). Among the other six patients, who had received Trazodone in the recommended dose range (50–300 mg/day), seizures had occurred 2–365 days after commencing therapy. An immediate release form of Trazodone HCl -- dosed up to 6 times daily was introduced in 1995 and is currently marketed in the United States under the brand name Ultram with sales of approximately $150 million and approximately 11 million prescriptions dispensed during 2003 including generics. Do not take a larger dose take it more often, or for a longer period than your doctor tells you to.

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